Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA
lesions, cells activate pathways referred to as the DNA damage response (DDR). As nuclear
DNA is bound by histone proteins and organized into chromatin in eukaryotes, DDR
pathways have evolved to sense, signal and repair DNA damage within the chromatin
environment. Histone proteins, which constitute the building blocks of chromatin, are highly …