Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF): Its identification as eRF3 interacting with eRF1
S Hoshino, M Imai, M Mizutani, Y Kikuchi… - Journal of Biological …, 1998 - ASBMB
Yeast GST1 gene, whose product is a GTP-binding protein structurally related to polypeptide
chain elongation factor-1α (EF1α), was first described to be essential for the G 1 to
Sphasetransition (GSPT) of the cell cycle, and the product was recently reported to function
as a polypeptide chain release factor 3 (eRF3) in yeast. Although we previously cloned a
human homologue (renamed as GSPT1) of the yeast gene, it has remained to be
determined whether GSPT1 also functions as eRF3 or if another GSPT may have such a …
chain elongation factor-1α (EF1α), was first described to be essential for the G 1 to
Sphasetransition (GSPT) of the cell cycle, and the product was recently reported to function
as a polypeptide chain release factor 3 (eRF3) in yeast. Although we previously cloned a
human homologue (renamed as GSPT1) of the yeast gene, it has remained to be
determined whether GSPT1 also functions as eRF3 or if another GSPT may have such a …
