Preventing chronic graft-versus-host disease (GVHD) remains challenging because the
unique cellular and molecular pathways that incite chronic GVHD are poorly understood.
One major point of intervention for potential prevention of chronic GVHD occurs at the time of
transplantation when acute donor anti-recipient immune responses first set the events in
motion that result in chronic GVHD. After transplantation, additional insults causing tissue
injury can incite aberrant immune responses and loss of tolerance, further contributing to …