Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types
C Wang, E Hahn, E Slodkowska, A Eskander… - Human Pathology, 2018 - Elsevier
Summary Programmed death-ligand 1 (PD-L1) expression by tumor cells is a mechanism for
down-regulation of antitumor T-cell responses and is a target for immunotherapy in various
cancers. PD-L1 status as a predictor of treatment response has led to the development of
multiple platforms with different reference cutoffs. We studied 128 cases of genitourinary and
head/neck carcinomas, aiming to assess the frequency of PD-L1 positivity, interobserver
reliability of PD-L1 interpretation, and the concordance of PD-L1 scoring between small …
down-regulation of antitumor T-cell responses and is a target for immunotherapy in various
cancers. PD-L1 status as a predictor of treatment response has led to the development of
multiple platforms with different reference cutoffs. We studied 128 cases of genitourinary and
head/neck carcinomas, aiming to assess the frequency of PD-L1 positivity, interobserver
reliability of PD-L1 interpretation, and the concordance of PD-L1 scoring between small …
