Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease
Background IgG 4-related disease (IgG 4-RD) is a systemic condition of unknown cause
characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T
cells constitute the major inflammatory cell population in IgG 4-RD lesions. Objective We
used an unbiased approach to characterize CD4+ T-cell subsets in patients with IgG 4-RD
based on their clonal expansion and ability to infiltrate affected tissue sites. Methods We
used flow cytometry to identify CD4+ effector/memory T cells in a cohort of 101 patients with …
characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T
cells constitute the major inflammatory cell population in IgG 4-RD lesions. Objective We
used an unbiased approach to characterize CD4+ T-cell subsets in patients with IgG 4-RD
based on their clonal expansion and ability to infiltrate affected tissue sites. Methods We
used flow cytometry to identify CD4+ effector/memory T cells in a cohort of 101 patients with …