The expression of vascular endothelial growth factor and its receptors in port-wine stains
E Vural, J Ramakrishnan, N Cetin… - … —Head and Neck …, 2008 - journals.sagepub.com
E Vural, J Ramakrishnan, N Cetin, L Buckmiller, JY Suen, CY Fan
Otolaryngology—Head and Neck Surgery, 2008•journals.sagepub.comObjective To investigate the expression of vascular endothelial growth factor (VEGF) and its
receptor (VEGF-R2) in port-wine stains (PWSs). Design An immunohistochemistry (IHC)
study on formalin-fixed, paraffin-embedded specimens. Methods Representative sections
from surgical resection specimens of 12 PWS patients and 12 control specimens stained
with routine IHC by using polyclonal anti-VEGF and anti–VEGF-R2 antibodies. Slides were
evaluated semiquantitatively for the intensity of staining for VEGF and VEGF-R2 by using a …
receptor (VEGF-R2) in port-wine stains (PWSs). Design An immunohistochemistry (IHC)
study on formalin-fixed, paraffin-embedded specimens. Methods Representative sections
from surgical resection specimens of 12 PWS patients and 12 control specimens stained
with routine IHC by using polyclonal anti-VEGF and anti–VEGF-R2 antibodies. Slides were
evaluated semiquantitatively for the intensity of staining for VEGF and VEGF-R2 by using a …
Objective
To investigate the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R2) in port-wine stains (PWSs).
Design
An immunohistochemistry (IHC) study on formalin-fixed, paraffin-embedded specimens.
Methods
Representative sections from surgical resection specimens of 12 PWS patients and 12 control specimens stained with routine IHC by using polyclonal anti-VEGF and anti–VEGF-R2 antibodies. Slides were evaluated semiquantitatively for the intensity of staining for VEGF and VEGF-R2 by using a scoring system varying from 0 to 3+.
Results
PWS specimens showed statistically significant overexpression of both VEGF and VEGF-R2 molecules when compared with control specimens (P < 0.005).
Conclusions
VEGF and its receptor may play an important role in the pathogenesis of PWS. It is possible that PWS may progress by hyperplasia in addition to hypertrophy. VEGF-R blockade may have a potential role as a targeted approach in the treatment of this disfiguring condition in the future.
Sage Journals